Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome

Article Abstract:

An attempt is made to show that intracellular nucleotides as well as many nucleotide derivatives apply a strong inhibitory effect on the cytochrome c (CC)-initiated apoptosome formation by directly binding to CC and inhibiting the interaction of CC with Apaf-1. The results have indicated that the intracellular nucleotides represent critical prosurvival factors by functioning as natural inhibitors of apoptosome formation and a barrier that cells must overcome the nucleotide barrier to undergo apoptosis cell death.

Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Nucleotides

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p53 and metabolism: Inside the TIGAR

Article Abstract:

The p53 tumor plays a direct role in cellular metabolism and this suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The product of a p53 target gene, TIGAR (TP53-induced glycolysis and apoptosis regulator), is identified and the discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

Analysis, DNA repair, Tumor suppressor genes, Glycolysis, Tumour suppressor genes

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Apoptotic pathways: Ten minutes to dead

Article Abstract:

Apoptosis and other forms of cell death are often controlled at one or more crucial steps involving the mitochondria. Mitochondrial outer membrane permeabilization (MOMP), cytochrome c-induced activation of APAF-1 and caspase activation is some of the procedures, which leads to the death of the cell.

United States, Mitochondrial membranes, Mitochondrial membrane

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