Isolation of a novel gene underlying Batten disease, CLN3

Article Abstract:

A study conducted on 142 haplotype families shows that the mutation causing Batten disease is on the CLN3 gene present in the chromosome containing the D16S299/D16S298 56 chromosome haplotype. All 56 of the chromosomes from patients of Batten disease take a deletion in the 3' end of the chromosome. The gene also has other mutations including two deletions and a point mutation. The function of the protein encoded by the mutated gene is unknown. Batten disease is a neurodegenerative disorder in children causing loss of vision, seizures and psychomotor disorders.

Nervous system, Mutation (Biology), Mutation, Nerve degeneration

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CLN3 functions in both daughter and mother cells of S. cerevisiae

Article Abstract:

CLN3 is a Saccharomyces cerevisiae G1 cyclin which is required for the progression of START and the regulation of cell size required for START. The regulatory activity of CLN3 was monitored in an isogenic pair of strains with a BF305-15D background (MATaleu2ura3his3trp1 ade1 met14arg5,6) and differing by a deletion in CLN3. The results showed that CLN3 functions in both mother and daughter cells.

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A suppressor of cln3 for size control

Article Abstract:

The role of CLN3 in daughter cells of Saccharomyces cerevisiae was investigated. Previous investigations showed that CLN3 could regulate START in mother cells but not in daughter cells. However, a reexamination of the experiments showed that CLN3 is also required in daughter cells. The previous findings were attributed to the presence of a suppressor mutation which masked the effects of CLN3.

Suppression, Genetic, Suppressor mutation (Molecular genetics)

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