The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons

Article Abstract:

Genetic criteria help define two genes unc-8 and sup-40 of Caenorhabditis elegans that control the ion channel function in motorneurons. Mutations in the mec-6 gene that codes for a sodium channel component inhibit unc-8 dominant mutations recessively. Both unc-8 and its mammalian homologue deg-1 undergo dominant, transacting intragenic suppressor mutations. The unc-8 motorneuron swelling is inhibited and a new swelling phenotype is formed in hypodermal nuclei by sup-40 mutations. A ion channel element or modulator that is encoded by sup-40 resets the abnormal unc-8-channel-induced osmotic defect.

Research, Physiological aspects, Motor neurons, Ion channels

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Mutations of the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing

Article Abstract:

A study of the mutations reveals that behavioral and developmental timing in Caenorhabditis elegans is affected by three allelic, maternal-effect mutations. Embryonic and postembryonic development are longer and the duration of pumping, swimming and defecation cycles are also made longer by these mutations. The temperature at which the parents were raised influences the embryonic developmental duration of the mutants. Biological clocks regulate many of the functions affected by the mutations.

Biological rhythms, Biorhythms

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Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans

Article Abstract:

A genetic screen for maternal-effect viable mutants in the nematode Caenorhabditis elegans were used to identify the genes involved in normal development. A total of 41 mutations falling into 24 complementation groups were identified. Genetic mapping of these 24 loci identified only two genes that encode mutations leading to morphological and behavioral defects. A chart showing phenotypic characterization of 22 genes is included.

Mutation (Biology), Mutation, Larvae

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