Jab1 is a specificity factor for E2F1-induced apoptosis

Article Abstract:

A yeast two-hybrid screen was used to identify proteins that bind the E2F1 marked box and flanking regions, with a potential role in E2F1 apoptosis induction. Jab1 was identified as an E2F1-specific binding protein and it was shown that Jab1 and E2F1 coexpression synergistically induce apoptosis, coincident with an induction of p53 protein accumulation.

United States, DNA repair

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Article Abstract:

Hippo signaling pathway plays an important role in controlling organ size by restricting both cell proliferation and apoptosis in Drosophila. Study is conducted to show that in mammalian cells, the transcription coactivator Yes-associated protein (YAP) is inhibited by cell density via the Hippo pathway.

Genetic aspects, Drosophila, Phosphorylation, Tumor suppressor genes, Cell proliferation, Tumour suppressor genes

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Article Abstract:

The transcriptional regulatory mechanisms involved in the biogenesis and energy metabolic function of mitochondria in higher organisms is reviewed. The mitochondrion serves a critical function in the maintenance of cellular energy stores, thermogenesis, and apoptosis.

Mitochondrial DNA, Thermogenesis, Genetic research

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