Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript

Article Abstract:

Short impulses of visible light induce the frequency (frq) gene, and clock resetting correlates to induction. Drugs that block the synthesis of protein or translatable RNA also block resetting. Other environmental factors such as temperature and feeding affect the circadian clock. The magnitude and speed with which induction of frq takes place indicate that this is the first clock-specific event in resetting. In constant light, the expression of frq remains high as frq negative autoregulation is overcome by light induction.

Analysis, Enzymes, RNA, Enzyme regulation

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Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript

Article Abstract:

The effects of light on the sequence homolog mPer1 of Drosophila per were examined to determine how light may entrain a mammalian circadian clock. mPer1 is quickly induced by short term exposure to light at sufficient levels to reset the clock. This shows reciprocity and strong correlation with phase changing of the overt rhythm. mPer1 is therefore similar to the frq Neurospora clock gene.

Observations, Drosophila

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