The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

Article Abstract:

TGIIH, a multisubunit complex that contains helicases, ATPase, and kinase activities, is implicated functionally in transcription by RNA polymerase II (RTNAPII). It is also functionally implicated in nucleotide excision repair. The largest subunit of RNAPII and the CDK7 subunit of TFIIH have been shown to become hyperphosphorylated in mitosis. MPF-induced phosphorylation of CDK7 brings on inhibition of the TFIIH-associated kinase and transcription activities. Phosphorylation in the T-loop of CDK7 is necessary for negative/positive regulation of transcription and the cell cycle.

Research, Observations, Cellular signal transduction, Cell cycle, Molecular biology, Mitosis, Phosphorylation

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Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

Article Abstract:

Research has been conducted on the adenovirus-induced p53 degradation. The mechanism of this degradation has been investigated via the E4orf6-associated cellular proteins and the details are reported.

Canada, Japan, Statistical Data Included, Analysis, Physiological aspects, Proteins, Adenoviruses, Genetic research, Ubiquitin

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