Lineage commitment in the immune system: the T helper lymphocyte grows up
Article Abstract:
The T helper lymphocytes and their function in the immune system are discussed in this review article. The current knowledge of signals that regulate lineage commitment in T helper cells is summarized with emphasis on three subset-specific transcription factors responsible for lineage commitment. They are T-bet, c-Maf and GATA-3. Topics include cytokines, development of the Th1 lineage and signaling pathways, interferons in the Th1 responses, APC, antigen and costimulation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
PGC-1[alpha] regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
Article Abstract:
The transcription of a neuromuscular junction gene is enhanced by the phosphorylation of PGC-1[alpha] and GA-binding protein. The control extended by the coactivator PGC-1[alpha] is found to be vital in the treatment of Duchenne muscular dystrophy.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Transcriptional regulation of adipogenesis
Article Abstract:
Research has been conducted on the molecular regulation of differentiation for specific cell types. The results of the experiments with the adipose tissue are described.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Novel ring cleavage products in the biotransformation of biphenyl by the yeast Trichosporon mucoides. Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus
- Abstracts: Drosophila p53 binds a damage response element at the reaper locus. p53: death star
- Abstracts: Hydra and the development of animal form: the 11th International Hydra Workshop. Hydra: an out-group moves toward the center
- Abstracts: Functional analysis of the flagellar genes in the fliD operon of Salmonella typhimurium. The Salmonella FigA protein, a putative periplasmic chaperone essential for flagellar P ring formation
- Abstracts: The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste. Functional antagonism between E2F family members