Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle, and bone

Article Abstract:

The latest developments in the organ systems like the heart, muscle and bone, which form a molecular framework for integrative physiology of human aging and related diseases is studied with reference to longevity and lineages. The results suggest that the latest developments are responsible for forming a basis for the new therapeutic strategies that are capable of delaying the advent of age-related disorders.

Science & research, Aging, Research, Aging (Biology), Degeneration (Pathology)

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A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages

Article Abstract:

Research demonstrates that the HF-1b transcription factor of cardiac conduction system and ventricular myocytes play a role in the sudden cardiac death in humans. Data reveal that the cardiovascular arrest is due to cardiac arrhythmogenesis brought about by a decrease and mislocalization of connexins and defects in the formation of ventricular Purkinje fibers.

Statistical Data Included, Cardiac arrest, Purkinje cells, Heart conduction system, Heart ventricles, Purkinje fibers

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A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I (sub)to and confers susceptibility to venticular tachycardia

Article Abstract:

Research has been conducted on the Kv channel-interacting protein 2 (KChIP2) gene expressed in the adult heart. Results indicate that the defect in KChIP2 confers a marked genetic susceptibility to arrhythmias and establishes a genetic pathway for the venticular tachycardia via the loss of the transmural gradient of I (sub)to.

Analysis, Causes of, Genetic aspects, Proteins, Gene expression, Tachycardia, Arrhythmia, Cell research, Cytological research

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