MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans
Article Abstract:
Studies have shown that a key determinant in the positioning of C. elegans Q neuroblasts is the novel transmembrane protein MIG-13. This protein was found to function outside the migrating cells in a dose-dependent fashion to determine the final stopping points for these Q cells and its descendants. Findings indicate that the MIG-13 protein is component of a global A/P migration system and that its levels determine its final stop along the body axis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Basic FGF as an inducer of anteroposterior neural pattern
Article Abstract:
The basic fibroblast growth factor (bFGF) acts as a second signal during the formation of the anteroposterior neural pattern in Xenopus embryos. Neuralized animal caps express the anterior and posterior neural markers in the presence of bFGF. The induction of the neural markers occurs by the direct action of bFGF without the presence of mesoderm. The bFGF is capable of repatterning the ectoderm after regional gene expression in older embryos.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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