Maturation dynamics of a viral capsid: visualization of transitional intermediate states

Article Abstract:

Visualization of transitional intermediate state is discussed relative to maturation dynamics of a viral capsid. Dynamic aspects of prohead maturation by exploiting the ability of acidic pH to bring on conversion of HK97. Prohead II to Head I in a controlled way. Expansion in vitro by acidic pH has been induced. The changes that resulted were watched using time-resolved X-ray diffraction and cryo-electron microscopy. Three distinct intermediates were seen. They are comarable to transitional states in protein folding. The structures show the molecular events that happen in expansion.

Viral research, Cytochemistry, Virus research, Cryobiochemistry, Herpesviruses, Molecular dynamics, X-rays, X-ray diffraction

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Origins of highly mosaic mycobacteriophage genomes

Article Abstract:

Research has been conducted on bacteriophages. The authors report that genomic sequence of isolated mycobacteriophages shows that bacteriophage population is diverse.

India, Analysis, Physiological aspects, Mycobacteria, Mycobacterium, Cell research, Cytological research

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Encapsidated conformation of bacteriophage T7 DNA

Article Abstract:

Experiment was conducted to investigate the DNA of T7, a moderate-sized bacteriophage. Image processing and cryo-electron microscopy (cryo-EM) technique, which has become a powerful method for visualizing macromolecular structures in their native states, were applied to T7 whose genome of 39,937 bp is enclosed in a thin-walled icosahedral capsid. Results indicate that the T7 chromosome is spooled around the axis in about six coaxial shells in a quasi-crystalline packing, possibly guided by the core complex on the inner surface of the connector.

Cover Story, DNA, Image processing, Microencapsulation

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