Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms
Article Abstract:
A thorough analysis of the expression and function of the cytosolic Hsp70 proteins in human cancer cells is presented and Hsp70-2, which is a protein essential for spermatogenesis is identified as an important regulator of cancer cell growth. The cancer cells experience a synergistic antiproliferative effect due to the concomitant depletion of the Hsp70 and Hsp70-2, thus demonstrating that the Hsp70 proteins lead to nonoverlapping functions that are essential for cell growth and survival.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Critical roles for Dicer in the female germline
Article Abstract:
Dicer, an essential component of the ribonucleic acid interference (RNAi) pathways, is necessary to control mouse oocyte gene regulation and genome organization. An examination of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline, essential for turnover of a substantial subset of maternal transcripts normally lost during oocyte maturation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion
Article Abstract:
Normal cell processes when thrown out of gear due to pathological changes, the importance of Dia1, leukemia-associated Rho-GEF and RhoA to normalize the process is presented.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effects of several factors of the heat-shock-induced thermotolerance of Listeria monocytogenes. Cold shock and its effect on ribosomes and thermal tolerance in Listeria monocytogenes
- Abstracts: Optimizing DNA yield from the buccal swabs in the elderly: attempts to promote buccal cell growth in culture
- Abstracts: Generation of pluripotent stem cells from neonatal mouse testis. A contextual model for axonal sorting into glomeruli in the mouse olfactory system
- Abstracts: Molecular genetics of the genus Paracoccus: metabolically versatile bacteria with bioenergetic flexibility. Adaptation and acclimation of photosynthetic microorganisms to permanently cold environments
- Abstracts: Heritabilities and additive genetic variances of the activities of some enzymes in Drosophila melanogaster populations living in different habitats