Methods of linkage analysis -- and the assumptions underlying them
Article Abstract:
The single-location P value may best indicate the probability that a gene is linked to a trait. Linkage analysis is an estimate of the number of recombinant genes relative to nonrecombinant genes within a genotype. An arbitrary score that describes a ratio of the maximum likelihood of genetic linkage to the likelihood when the recombinant fraction of 50% can be used in linkage analysis. The best analytical models are uncertain when considering complex multigenetic traits. Determination of statistical significance in linkage analysis remains an ongoing debate.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages
Article Abstract:
Significant increases in loci-mapping power can be achieved through multiple phenotype modeling. This simple statistical model reduces the costs of typical gene-mapping procedures such as those with larger sample sizes, novel subject-ascertainment schemes and greater DNA marker density. It incorporates multiple diagnostic and phenotypic endpoints with quantitative-trait loci to create a gene-mapping analysis.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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