Tailored Hox gene transcription and the making of the thumb
Article Abstract:
A report is presented on the quantification of the expression of the 5' members of the HoxD cluster in normal and rearranged configuration and on the design of a mathematical model of the regulatory circuit driving the late phase of Hoxd gene. An additional outcome of the quantitative regulation of the 5' Hoxd genes, the ontogeny of a distinct morphology of digit 1, the thumb, is proposed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
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Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila
Article Abstract:
The control of myc in Drosophila is examined and it is shown that the Drosophila ortholog, dmyc, undergoes autorepression. The result suggests that the developmental repressor Polycomb (Pc) is required for dmyc autorepression, and this Pc-dMyc-mediated repression spreads across an 875-kb region encompassing the dmyc gene.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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