Modulation of Aspergillus awamori thaumatin secretion by modification of bipA gene expression

Article Abstract:

A study shows that over expression of the bipA gene in Aspergillus awamori causes an increase in the secreted levels of the heterologous protein thaumatin and that there is an optimal level of bipA expression, above which the secreted levels of thaumatin decrease. Hence the bipA protein is very important for secretion of some heterologous proteins, such as thaumatin in A. awamori.

Genetic aspects, Proteins, Gene expression, Microbiological research

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Characterization of humanized antibodies secreted by aspergillus niger

Article Abstract:

Two different humanized immunoglobulin G1(k) antibodies and a Fab' fragment are developed with the help of Aspergillus niger. According to tests for affinity, avidity, pharmacokinetics, or anti-body dependent cellular sytoxicity function, there was no significant difference between the glycosylated antibody produced and that produced by mammalian cell cultures.

Microbiology, Immunoglobulins

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