Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion

Article Abstract:

Molecular and genetic analyses of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion, were done. Northern analysis showed that unc-7 is a 2. 7-kilo base gene whose product is present in all developmental stages but is most abundant in L1-L3 larvae. The cDNA corresponding to the unc-7 message showed that it encodes for a 60-kd protein with unknown amino acid sequence. The unc-7 gene product may be required in motor neurons and may be involved in the function of neuronal ion channels.

Motor neurons, Ion channels, Animal locomotion, Crawling and creeping

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The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously

Article Abstract:

Polarity reversals occur in some asymmetric cell divisions of the nematode Caenorhabditis elegans due to mutations in the lin-44 gene. Secretory glycoproteins, which are involved in intercellular signalling, are encoded by lin-44. The gene belongs to the Wnt family of genes and is not cell autonomous. Hypodermal cells at the tip of the nematode tail contain lin-44. Lin-44 containing cells also occur behind cells affected by the gene mutations.

Physiological aspects, Gene expression, Cell division

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Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33

Article Abstract:

A study was conducted to analyze Caenorhabditis elegans unc-33 gene mutations. These mutations caused severely uncoordinated movement, abnormal guidance and outgrowth of neuron axons and excessive microtubules in neuronal processes. Three unc-33 messages were prepared after the gene was cloned with Tc4. Results show that the three polypeptides overlapped in C-terminal sequence but had varied positions at mutation starting points.

Axons, Mutation (Biology), Mutation

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