Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations
Article Abstract:
Seven East Asian populations were subjected to a detailed mitochonrdial (mt) DNA analysis to determine the interrelationships and ancestry of the human populations in this region. The results showed that all the Southeast Asian populations have common origins, confirming an earlier hypothesis of a southern Mongloid origin of the populations in this region. The oldest population which formed the center of mtDNA radiation is the Southern Chinese population. Relationships were identified between populations from the Malay peninsula, Sabah and Papua New Guinea. Coastal Asians were characterized by a marked frequency cline for the COII/tRNA-Lys intergenic deletion.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations
Article Abstract:
A mitochondrial DNA analysis was conducted on the Amerind and Nadene populations of native American Indians. Detailed restriction pattern analysis revealed four distinct lineages constituting all native American populations. Each lineage could be identified by a particular mutation, which can be used as a genetic marker for these populations. Sequence divergence analysis also showed that the Amerind and the Nadene populations originated from separate founder populations, with the Amerind sequence data revealing an older lineage. The findings also revealed the possibility of a third source of mtDNA in American Indians.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy
Article Abstract:
Most cases of Leber's hereditary optic neuropathy (LHON) can be attributed to a mitochondrial (mt) DNA mutation at nucleotide pair 11778. However, some LHON patients do not have this mutation. Mitochondrial DNA sequence analysis of 25 non-11778 LHON patients showed that LHON could also be attributed to a mutation in a highly conserved amino acid of the mtDNA cytochrome b gene of respiratory complex III. In addition, other mutations in the ND2, ND5 and cytochrome b genes could add to the deleterious effects of the primary non-11778 mutation.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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