Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
Article Abstract:
MHC class II binding and T cell receptor recognition require some nucleotide residues that are identified by the structural characterization of the immunodeficient myelin basic protein (MBP). Mutational analysis of the residues helps identify the amino acids at each critical position. Bacterial and viral peptides obtained from a search of protein sequence data base exhibit the ability to activate MBP-specific T cell clones and serve as molecular mimics of the immunodominant MBP peptide. Molecular mimicry of this peptide by viruses serves as a pathway for the stimulation of autoimmunity in multiple sclerosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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A role for CaMKII in T cell memory
Article Abstract:
A previously unrecognized role for calcium/calmodulin kinase II (CaMKII) in T cell memory has been defined. Transgenic mice expressing CaMKII gamma B (T287D), partially calcium-independent mutant of CaMKII gamma B, have been generated. An increase in the number of T cells in the secondary lymphoid organs that had gained an antigen-dependent memory phenotype was seen. The cells were found to be actual memory cells. CaMKII seems to regulate a definite process of activation-induced cellular differentiation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Glycosylation, immunity, and autoimmunity
Article Abstract:
Immunity, autoimmunity, and glycosylation are discussed in this minireview article. Substantial combinatorial potential of oligosaccharide structure gives huge potential for information display. Topics include immune phenotypes in mice with induced genetic alteration in O-glycan synthesis and specific complex-type N-glycans in control of T cell activation/autoimmunity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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