Moving membrane up to the front migrating cells
Article Abstract:
The polarized endocytic cycle assist in the transfer of a cell's feet from the rear to the front. The cytoskeleton assists in the putative intracellular transport of vesicles to the advancing edge of the cell. This cytoskeletal function is exhibited by the migration of axonal mitochondria along the microtubules and microfilaments to the leading edge of the cell. The polarized endocytic cycle also provides a fresh source of cell surface and integrins. Cellular exocytosis also occurs at the leading edge of the cell while endocytotic activity occurs randomly at the cell surface.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Dynamin undergoes a GTP-dependent conformational change causing vesiculation
Article Abstract:
The function of dynamin in the formation of vesicles during receptor-mediated endocytosis is investigated using a novel assay. Results reveal that the protein binds anionic phospholipids forming tubular structures. The addition of GTP induces structural changes that constrict the tubules and forms a number of small vesicles. This is postulated to be an important step before clathrin-coated pits bud off from the cell membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Getting membrane flow and the cytoskeleton to cooperate in moving cells
Article Abstract:
A comparison of two different views of the molecular mechanism of antigen cap formation reveals that the flow mechanism is a more plausible perspective than the rake scheme, since it seems to explain cap formation and particle migration naturally. The flow mechanism involves a polarized endocytic cycle, wherein both microtubules and microfilaments cause the intracellular transport of endocytosed membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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