Myc activates telomerase
Article Abstract:
Telomere maintenance may be necessary for tumor development in humans. The telomerase enzyme is a marker for tumor cells, but the genetic changes that activate it in neoplastic transformation are not well understood. Myc brings on telomerase in normal human diploid fibroblasts and in normal human mammary epithelial cells (HMECs). Myc ups expression of hEST2 (hTRT/TP2). hEST2 is the limiting subunit of telomerase. hEST2 and Myc can prolong the life of HMECs. Myc's ability to activate telomerase may be a factor in its ability to promote formation of tumors.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
Article Abstract:
The single-stranded telomere DNA binding-protein in the protozoan Oxytricha inhibits telomerase and contributes to maintaining the length of the telomere by making telomeric DNA inaccessible. The protein has alpha and beta subunits that can displace telomerase because of their greater affinity for the DNA. The alpha subunit apparently plays a role in length regulation. Moreover, the alpha-beta-DNA complex does not act as a substrate for terminal deoxynucleotidyltransferase.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Telomere-mediated chromosome pairing during meiosis in budding yeast
Article Abstract:
Telomere-mediated chromosome pairing has been studied in meiosis in budding yeast. From analysis of a disome with two linear permuted chromosomes, it can be seen that likely even nonhomologous chromosome ends can promote homolog pairing in a limited way. It may be that telomere-mediated chromosome movement and/or telomere clustering aid in homolog pairing.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
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