The Cdc7 protein kinase is required for origin firing during S phase

Article Abstract:

The Cdc7p protein kinase is necessary for promoting S phase in Saccharomyces cerevisiae as it buds. The B1-S transition happens in the cell cycle and precedes activation of individual origins, but is not part of the activation. Partial loss of Cdc7 activity brings on slow progress through S phase, not slow entry into it. Cdc7 protein kinase is needed for finishing of S phase after a block to elongation with hydroxyurea. Cdc7 is necessary for activation of late-firing origins following the hydroxyurea block. Cdc7 seems to have a direct role in firing of replication origins during S phase, not being the global regulator of the G1-S transition.

DNA

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S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

Article Abstract:

Activation of Cds1 kinase that is S-phase-specific gives definition of a subpathway of the checkpoint response in Schizosaccharomyces pombe. Cds1 kinase is necessary to slow S phase where there are of DNA-damaging agents. Cds1 is not necessary for the mitotic-arrest checkpoints; it defines an S-phase specific subpathway of the checkpoint response. That is different from what happens with the Saccharomyces cerevisiae counterpart, Rad53. It seems that an intrinsic mechanism linking S phase and mitosis may work in a way that is independent of known checkpoint proteins.

DNA damage

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E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

Article Abstract:

More than half the genes that code for initiation proteins are activated after stimulation of cell growth. They are regulated by E2F. With other findings this has led to a proposal that E2F3 activity is important in the cell cycle of proliferating cells and controls expression of genes whose products are rate limiting for starting DNA replication. That would give greater control of entry into S phase than would be possible from post-transcriptional control by itself.

DNA binding proteins

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