Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis

Article Abstract:

Human SAP 155 (spliceosome-associated protein) cDNA has been isolated and a Saccharomyces cerevisiae homolog has been found that is 50% identical to human SAP 155. Phosphorylation of SAP 155, a U2 snRNP component, appears to play a significant role in splicing. Phosphorylation of SAP 155 is coupled with splicing catalysis, and the phosphorylated SAP 155 is in contact with both sides of the branch site as the spliceosome complex assembles.

Phosphorylation, Catalysis

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A ribosomal function is necessary for efficient splicing of the T4 phage thymidylate synthase intron in vivo

Article Abstract:

Ribosome works with RNA to ease the proper folding of the intron. Using stop codons in the upstream exon delinked the translation from the splicing in the group I intron of the T4 thymidylate synthase (td). There was splicing deficiency. The RNA chaperone ribosomal protein S12 and CYT-18 helped alter the mutants and the region interfering with the splicing was identified.

Ribosomal proteins

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Ironing out the kinks: splicing and translation in bacteria

Article Abstract:

The RNA substrate has to perform different functions in bacteria splicing and translation as opposed to eukaryotic cells.Splicing requires an elaborate tertiary structure and translation requires comparative freedom from secondary structure. This contradiction is addressed and the results have implications for coupling of eukaryotic pre-mRNA splicing and translation.

Genetic aspects, Bacteria

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