Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
Article Abstract:
Research has been conducted on left-right asymmetry generation in the vertebrate body. The authors demonstrate that Notch signaling is important for the asymmetry establishment in mice carrying it out via Nodal gene expression regulation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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Roles for Nkx3.1 (ital) in prostate development and cancer
Article Abstract:
The mouse Nkx3.1 (ital) homeobox gene has roles in prostate development and in cancer. This gene is the earliest known marker of prostate epithelium in embryogenesis and is expressed after that at all stages of prostate differentiation in vivo and in tissue recombinants. NKX3.1 (ital) may be a prostate-specific tumor suppressor gene. Loss a single allele may constitute a predisposition to carcinogenesis in the prostate.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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