The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure

Article Abstract:

The Drosophila tyrosine kinase called SH2 domain ankyrin repeat kinase (Shark) is necessary for embryonic dorsal closure. Flies with a Shark tyrosine kinase gene mutation, shark (super.1) show a DC-defective phenotype. Dpp is not expressed in shark(super.1) mutant leading edge (LE) cells. Shark regulates the NJNK signaling pathway to Dpp expression in LE cells/

Epithelial cells, Protein tyrosine kinase, Protein-tyrosine kinase

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Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

Article Abstract:

Import to the nucleus of the Rel protein, Dorsal, is regulated in Drosophila by phosphorylation. The formation of a wild-type Dorsal nuclear gradient requires the phosphorylation of both Cactus, an I-kappa-B protein, and Dorsal. The strong conservation of the serines would seem to indicate that phosphorylation of other Rel proteins is necessary for the nuclear targeting to be accurate. An in-depth study of the functional importance of Dorsal phosphorylation has been carried out, and it was found that Dorsal is phosphorylated by the ventral signal while associated with Cactus.

Proteins, Phosphorylation, Cell receptors, Cell nuclei, Cell nucleus

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Recruitment of Nanos to hunchback mRNA by Pumilio

Article Abstract:

Recruitment of Nanos to hunchback (hb) mRNA by Pumilio is discussed. Nanos and Pumilio are trans-acting factors. Protein-protein and protein-RNA interaction assays have been done in yeast in vivo and in purified components in vitro and have shown that Nanos forms a ternary complex with the RNA-binding domain of Pumilio and the Nanos response elements (NRE). Translational regulation of hb mRNA is necessary for posterior patterning of the Drosophila embryo. Pum-like proteins from other species may act by recruiting cofactors to regulate translation.

Statistical Data Included, Genetic regulation, RNA splicing, Messenger RNA, Genetic translation, Translation (Genetics)

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