Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer
Article Abstract:
A study was conducted to better understand how chromatin accessibility complex (CHRAC) 'mobilizes' nucleosomes and contribute to the elevation of the accessibility of nucleosomal DNA in an adenosine triphosphate-dependent (ATP) manner. Results indicate that CHAC triggers the sliding of intact histone octamers to neighboring DNA segments without causing their displacement to competing DNA or histone chaperones in trans. It was also observed that the catalytic core of CHAC, the recombinant ATPase ISWI, helps in the mobilization of nucleosomes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Wapl controls the dynamic association of cohesion with chromatin
Article Abstract:
A study shows that the interaction between cohesin and chromatin is controlled by Wapl, a protein implicated in heterochromatin formation and tumorigenesis. The findings reveal that Wapl is associated with cohesin throughout the cell cycle, and its deletion blocks cohesin dissociation from chromosomes during the early stages of mitosis and prevents the resolution of sister chromatids until anaphase, which occurs after a delay.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
Article Abstract:
Research demonstrates that murine Suv39h histone methyl transferases mediate methylation of pericentric heterochromatin. Mice deficient in Suv39h exhibit severely impaired viability and chromosomal instability. Data suggest that Suv39h methyltransferases are epigenetic regulators of mammalian development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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