O-antigenic determinants in Salmonella species of serogroup C1 are expressed in distinct immunochemical populations of chains
Article Abstract:
The complexity and expression of O-antigenic determinants in Salmonella species of serogroup C1 was investigated. The O-antigenic determinants were found to be distinct and unrelated as shown by monoclonal antibodies analysis consistent with classical serology findings. Immunoblotting of mAbs against electrophoretically resolved lipopolysaccharides (LPS) demonstrated that epitopes related to factors O:6 sub-1 and O:6 sub-2 are expressed only in LPS with high molecular mass while those associated with O:7 sub-2 and O:7 sub-3 are expressed in relatively low molecular mass chains.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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FliL is a membrane-associated component of the flagellar basal body of Salmonella
Article Abstract:
Research was conducted to prove that FliL, one of the least understood proteins in the flagellar systems of Salmonella and Escherichia coli, is a component of the basal body and is located in the cytoplasmic membrane. Despite the fact that it has a sequence that conforms to the consensus cleavage site for lipoproteins, FliL does not undergo cleavage or modification under physiological conditions. It was also shown that processing and lipoylation of FliL takes place to a very small degree, if it ever occurs at all.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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Characterization of novel immunodominant antigens of Mycobacterium tuberculosis
Article Abstract:
The genes coding for seven new Mycobacterium tuberculosis antigens identified based on serum reaction of patients were sequenced. Two of these antigens are FtsH and an aminoimidazole ribotide synthase. Antibodies raised against the recombinant forms of these antigens were used to localize them in subcellular compartments and identify their distribution across the genus Mycobacterium. The genes for four of the seven novel antigens discovered were conserved in pathogenic Mycobacterial strains.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1998
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