Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants

Article Abstract:

A comprehensive study of the effects of polymorphisms in genes involved in detoxification pathways is reported along with the interaction effects between these genetic variants and maternal cigarette smoking on the common birth defect of orofacial cleft (OC) in infants. Results reveal that maternal smoking is interactive with specific detoxification-gene variants, thus increasing OC risk in infants.

Genetic aspects, Detoxification (Substance abuse treatment), Cleft lip, Smoking in pregnancy

---

No gene is an island: The flip-flop phenomenon

Article Abstract:

Theoretical modeling is used to show that flip-flop associations can occur when the examined variant is correlated, through interactive effects or linkage disequilibrium with a casual variant at another locus. The analysis has demonstrated that flip-flop associations are partially attributable to population variation in interlocus correlation when the loci are not taken into consideration jointly.

Allelomorphism, Alleles, Genetic variation

---

X-APL: An improved family-based test of association in the presence of linkage for the X chromosome

Article Abstract:

A novel and improved modification of the test for association in the presence of linkage, X-APL, is proposed for testing markers on the X chromosome in family data sets. The X-APL can use singleton or multiplex families to properly infer missing parental genotypes in linkage regions, can be utilized in real-data analysis of candidate genes and is more effective than alternate tests.

Methods, Genetic screening, Genetic testing, Genetic markers, X chromosome

Similar abstracts:

• Abstracts: The transcriptional activity of nf-kb is regulated by the ikb-associated pka subunit through a cyclic amp-dependent mechanism
• Abstracts: Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues
• Abstracts: A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants
• Abstracts: Occurrence of sep insecticidal toxin complex genes in Serratia spp. and Yersinia frederiksenii. Virulence of Serratia strains against Costelytra zealandica
• Abstracts: A protein of the sea urchin cortical granules is targeted to the fertilization envelope and contains an LDL-receptor-like motif

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.