A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants

Article Abstract:

A flexible Bayesian framework is proposed for modeling haplotype association with disease in population-based studies of candidate genes or small candidate regions to describe the correlation between marker-single-nucleotide-polymorphism (SNP) haplotypes and causal variants at the underlying functional polymorphisms. The dominance effects of causal variants corresponding to any deviation from a multiplicative contribution to disease risks are accounted for, demonstrating minimal cost of modeling and significant gains in power over other methods.

Bayesian statistical decision theory, Bayesian analysis

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Multipoint linkage-disequilibrium mapping with haplotype-block structure

Article Abstract:

New methods are developed for case-control multipoint linkage-disequilibrium (LD) mapping that gain power and speed by making explicit use of the inferred block structure. The haplotype-block structure helps the analysis stage of multipoint LD mapping by greatly increasing the power to detect association with untyped variants and improved localization of untyped variants associated with the trait.

Crohn's disease, Report

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Leveraging the Hapmap correlation structure in association studies

Article Abstract:

A novel multimarker indirect-association method based on a weighted sum of the haplotype frequency differences is proposed. It is shown analytically that there is a considerable gain in power achieved by this method compared with both single-marker and multimarker tests, as well as traditional haplotype-based tests.

United States, Methods, Genetic screening, Genetic testing, Genetic markers

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