Parallel DNA triplexes, homologous recombination, and other homology-dependent DNA interactions
Article Abstract:
Homologous genetic recombination is the process of genetic information exchange at equivalent positions along the length of two chromosomes with substantial overall sequence identity resulting in neither the loss nor gain of a single nucleotide at the joint. Models of homologous recombination are reviewed including the copy choice model, the Meselson-Radding model and the double-strand-break repair model. Homologous recombination forming three-stranded joint molecules resulting in DNA triplexes upon deproteination is also discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes
Article Abstract:
Chromosomal translocations were studied by forming a fusion oncogene to mimic homologous recombination in embryonal stem cells. The fusion oncogene consisted of the human AF9 sequences which were mated into the mouse MII gene, which contains the transcription control elements similar to human leukemia. Expression of the fused genes produced tumors in chimeric mice. Prior to the development of tumors, the embryonal cell derivatives showed forms of expansion in peripheral blood.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres
Article Abstract:
A model is proposed that suggests that a relationship between telomeres, DNA replication and the DNA damage machinery is required for the formation of a functional telomere. The results have shown that the telomeres are not hidden from DNA damage machinery during the cell-cycle and that detection processing of natural chromosome ends is a necessary step for chromosome end protection.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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