Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
Article Abstract:
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. In development of the vertebrate embryo, genes encoding components of the Notch signaling pathway are needed for subdividing the paraxial mesoderm into repeating segmnetal strucures called somites. The genes are thought to function in the presomitic mesoderm when cells form future somites. Two novel genes, ESR-4 and ESR-5 have been identified. They are transcriptionally activated in the somitomeres of Xenopus embryos by the su(H)-dependent Notch signaling pathway. The expression of the genes divides each somitomere into an front half and a back half. The pattern of expression is generated by repressing expression of the Notch pathway genes actively when paraxial cells enter a critical region and form a somitomere.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
Article Abstract:
The Hox gene Ultrabithorax (Ubx) controls the development of wing and haltere in Drosophila through selective, independent regulation of genes at various levels of the wing-patterning hierarchy. Halteres are posterior flight appendages, smaller and morphologically different than wings. Ubx represses expression of specific genes in the anteroposterior axis, the dorsoventral axis, and the proximodistal axis to change a wing field into a haltere field.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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