Perspective: Machines for RNAi
Article Abstract:
The current understanding related to the production of small ribonucleic acid (RNAs), the process concerning their loading into the protein complexes and the repression of the gene expression is reviewed. Various issues related to RNAi silencing and RNAi machinery are detailed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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RISC is a 5' phosphomonoester-producing RNA endonuclease
Article Abstract:
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). The mutational analysis of the target RNA, mismatches across from the 5' end of siRNA, and their effects are discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Life beyond cleavage: The case of Ago2 and hematopoiesis
Article Abstract:
The article discusses the role and function of Ago2 for hematopoietic development as well as miRNA biogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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