Ponce d'elegans: genetic quest for the fountain of youth
Article Abstract:
The role of genes in controlling the aging process has been evident in some experiments. Single-site mutations that change some aspects of aging have been discovered. Mutation of the SIR4 gene of yeast lengthened its life span by deactivating a gene responsible for senescence. Mutation of the age1 gene of Caenorhabditis elegans increased its life span by 60%. The daf-2, daf-23 and clk genes have also been found to increase C. elegans' life span.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
Article Abstract:
Research examines the interaction of several tissues specify the lifespan of the animal. The tissues act as signaling centers and the transcription factor DAF-16 may regulate two types of downstream signals. Data suggest such tissue interactions and feedback regulation allow the tissues fine-tune the expression of downstream genes, which coordinaes the rate of aging within the animal.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Conversion of a gene-specific repressor to a regional silencer. The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent origin-specific long-distance insulation and methylation-free domains
- Abstracts: Population genetic structure of the cleistogamous plant species Viola pubescens Aiton (Vioaceae), as indicated by allozyme and ISSR molecular markers
- Abstracts: Reproductive and genetic consequences of forest fragmentation: two case studies of neotropical canopy trees. Breeding population size of a fragmented population of a Costa Rican dry forest tree species
- Abstracts: Inheritance of black-pod color in peanut. Inheritance of a rusty-leaf trait in peanut. Inheritance of a lutescent-leaf color trait in peanut
- Abstracts: Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. part 2 Amyotropic lateral sclerosis: unfolding the toxicity of the misfolded