Production of the potent antibacterial polyketide erythromycin C in Escherichia coli
Article Abstract:
An Escherichia coli strain capable of producing the potent antibiotic erythromycin C (Ery C) is developed by expressing 17 new heterologous genes in a 6-deoxyerythronolide B (6dEB) producer strain. The megalomicin gene cluster is used as the source for the construction of two artificial operons that contained the genes encoding the deoxysugar biosynthetic and tailoring enzymes necessary to convert 6dEB to Ery C.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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Recovery of Escherichia coli from soil after addition of sterile organic wastes
Article Abstract:
A hypothetical study was conducted to prove that addition of biosolid nutrients to soil would enhance recovery of Escherichia coli naturally found in soil. The experimental effect was most marked for the deeper soil layers, with increases of about 2.6 orders of magnitude in E. coli most probable number.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2006
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Stress responses as a tool to detect and characterize the mode of action of antibacterial agents
Article Abstract:
Research conducted on stress and cold shock responses in Escherichia coli to detect and characterize antibacterial compounds is presented. Results include natural source antibiotics identification.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1999
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