The crystal structure of dimeric kinesin and implications for microtubule-dependent motility
Article Abstract:
X-ray crystallography has been used to solve the dimeric form of kinesin motor and neck domain from rate brian with bound ADP. The two dimer heads are linked by a coiled-coil alpha-helical interaction and are broadly similar. The heads have rotational symmetry around an axis near to the coiled-coil. The arrangement is not compatible with the microtubule lattice.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor
Article Abstract:
The vascular endothelial growth factor (VEGF) homodimeric hormone induces endothelial cell proliferation, by binding to the kinase domain receptor and Flt-1, a tyrosine kinase receptor. It is shown that Flt-1 third domains are required for binding VEGF with near-native affinity. A model of VEGF found to the first four Flt-1 domains is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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