Signaling reaches to new dimensions in Drosophila imaginal discs

Article Abstract:

Signal transduction in the imaginal discs of Drosophila occurs between cell layers via long cytoplasmic extensions. Research suggests that the interconnecting cell extensions function as conduits for signals or function as sensors.

United States, Sensory receptors, Optic disc

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Proteolysis that is inhibited by hedgehog targets cubitus interrupts protein to the nucleus and converts it to a repressor

Article Abstract:

The effect of cubitus interruptus (Ci) protein, Ci75, on hedgehog (Hh) signal transduction was analyzed through gel filtration assay and immunohistochemistry of Ci core DNA constructs. Aside from functioning as a transcription factor that represses hh expression, Ci establishes itself in the cytoplasm of anterior cells to induce a form that translocates to the nucleus where hh is repressed. Furthermore, the inhibition of proteolysis of Ci by hh results to patterns of expression of target genes.

Proteolysis, Hedgehogs

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Cytonemes: cellular processes that project to the principal signalling center in Drosophila imaginal discs

Article Abstract:

A study was conducted to determine the nature and functional properties of thin, actin-based extensions called cytonemes in cells. Experiments with the Drosophila revealed that cytonemes are formed when cells from the lateral flanks of a wing disc are cultured next to a source of fibroblast growth factors. On the other hand, experiments with mouse limb bud cells showed that cytonemes are induced during a brief culture period. These experiments provided evidence that support cytonemes' potential involvement in cell-cell communication.

Mice, Mice (Rodents)

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