Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
Article Abstract:
A cytoplasmic protein, Rabaptin-5, is necessary for the function of Rab5, the regulator of endocytic transport. Rabaptin-5 is a 100kDa protein that is found in the cytosol. Rabaptin-5 binds to GTP-bound Rab5 which can then bind to early endosomes. The overexpression of rabaptin-5 changes the morphology of the early endosome compartment. Low levels of rabaptin-5 in the cytosol suppress endosome fusion brought about by Rab5.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
Article Abstract:
Rab5, a small GTPase, is important in endocytic traffic processes. A novel 60 kDA Rab5-binding protein Rabex-5 has been determined. It forms a tight physical complex with Rabaptin-5 which is essential for endocytic membrane fusion. Nanoelectrospray mass spectrometry and cloning to sequence the mammalian Rabex-5, revealed a striking homology to the yeast protein Vps9p, implicated in endocytic traffic.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Caveolin-stabilized membrane domains as multifunction transport and sorting devices in endocytic membrane traffic
Article Abstract:
Endocytosis comprises several routes of internalization and it involves multiple mechanisms. The composition and morphology of early endosomes, which most incoming ligands encounter as the first sorting compartment, reflects the broad functional diversity of endocytic organelles.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo
- Abstracts: Strategy for in situ detection of natural transformation-based horizontal gene transfer events. Synthetic consolidants attacked by Melanin-producing fungi: Case study of the biodeterioration of Milan (Italy) cathedral marble treated with Acrylics
- Abstracts: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
- Abstracts: Antigenic variation in malaria. A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei
- Abstracts: pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos