Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-activating protein activity in larval neurons
Article Abstract:
The Drosophila neurofibromatosis type 1 (NF1) growth defect has reflected a non-cell-autonomous requirement for NF1 in larval neurons that express the R-Ras ortholog Ras2, that NF1 is a GTPase-Activating Protein (GAP) for Ras1 and Ras2, and that a functional NF1-GAP catalytic domain is both necessary and sufficient for rescue. The results have shown that loss of NF1 can give rise to non-cell-autonomous development defects and implicated aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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The hematopoietic stem cell and its niche: a comparative view
Article Abstract:
The various aspects and importance of the hematopoietic stem cell in different organisms are discussed. Further an explanation about the microenvironment required for the cell, which is also referred to as its niche.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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