Redundancies, development and the flow of information

Article Abstract:

Experimental findings of gene redundancies, or the overlapping of gene functions, warrants a modification of the long-held assumption in genetic studies that mutation in a single gene results in a particular phenotype, which in turn reveals something about the function of the gene. Mutagenesis experiments will benefit from the awareness that in some cases, a single phenotype is controlled by more than one gene. Redundancy in a system is also indicative of age in terms of evolution because it takes some evolutionary time to recruit a number of genes for a single phenotype.

Evaluation, Mutation breeding

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Regulation of hematopoietic niches by sympathetic innervation

Article Abstract:

Study is presented which proposed that signals through the sympathetic nervous system are found to modify the activity of the hematopoietic niche, acting as regulators of the mobilization of hematopoietic progenitors. The results have added a new level of complexity to the cellular milieu responsible for generation and maintenance of the hematopoietic niche.

Hematopoietic agents

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Cell-type-specific regulation of RNA polymerase I transcription: A new frontier

Article Abstract:

The cell-type-specific regulation of ribosomal RNA transcription is systematically studied. Several issues concerning the cell-type-specific requirement for rRNA production, the universality of Pol I transcription complex and the division of rDNA into regulatory subdomains are discussed.

Genetic transcription, Transcription (Genetics), RNA polymerases

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