Regulating the fate of mRNA: the control of cellular iron metabolism
Article Abstract:
Iron metabolism in mammalian cells is a coordinately regulated process involving the posttranscriptional regulation of transferrin receptor and ferritin proteins. Central to these processes are the iron-responsive element (IRE) and the IRE binding protein (IRE-BP), which modulate at least two genes in iron metabolism at the translational level and at the level of mRNA degradation. Further molecular aspects of the IRE-BP system are discussed, and a working model for the regulation of IRE-BP is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Identification of an intestinal heme transporter
Article Abstract:
A subtractive hybridization approach is utilized to isolate a heme transporter from duodenum by taking advantage of the intestinal gradient for heme absorption. A membrane protein named HCP1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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The intestinal heme transporter revealed
Article Abstract:
A heme transporter that is expressed in the apical region of epithelial cells in the mouse duodenum is described. The transporter, called as heme carrier protein 1 (HCP1) is highly conserved and is part of a larger family of transporters known as the major facilitator super-family (MFS).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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