Regulation of myogenesis in paralyzed muscles in the mouse mutants peroneal muscular dysgenesis
Article Abstract:
The mouse mutants peroneal muscular atrophy and muscular dysgenesis were used to study the effects of muscle innervation, electrical activity and contraction on the development of myotubes during embryonic development. During embryonic day 15, the ratio of secondary to primary myotubes was three times greater than normal. Furthermore, administration of tetrodoxin to induce paralysis significantly reduced the number of secondary myotubes and resulting in a smaller ratio. These results indicate that secondary myotube formation depends on the electrical activity produced by primary myotubes.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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Formation of primary and secondary myotubes in aneural muscles in the mouse mutant peroneal muscular atrophy
Article Abstract:
An experiment conducted to study skeletal muscle development in the mouse mutant peroneal muscular atrophy (pma) muscular indicate that the formation of secondary myotubes is not nerve-dependent. A higher ratio of secondary to primary myotubes was recorded in the pma as compared to normal strains. Furthermore, no difference was observed between aneural and normal muscles in terms of myotube ratio. These results, along with similar studies conducted on chicks, indicate that innervation doe not directly affect secondary myotube formation.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
User Contributions:
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Formation of myotubes in aneural rat muscles
Article Abstract:
An experiment was conducted to test whether the formation of secondary myotubes in aneural fetal muscles is dependent on the presence of primary myotubes or on innervation. Attempts to suppress secondary myotube formation using the neurotoxic agent Beta-bungarotoxin (Beta-BTX) indicated that the influence of Beta-BTX is dependent on the timing of injection. Results provided evidence for the hypothesis that secondary myotube formation is nerve-dependent.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
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