The isolation of mutagen-sensitive nuv mutants of Aspergillus nidulans and their effects on mitotic recombination
Article Abstract:
Twenty-three mutants that were hypersensitive to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 4-nitroquinoline-1-oxide (4-NQO) were isolated and studied for their effects on spontaneous intragenic recombination. Ten of these had no significant effects on recombination. Reactions to different concentrations of MNNG and 4-NQO were varied. Most of the nuv mutations were fully recessive and only a few were semidominant. Six nonallelic loci were identified in trans complementation analysis of seven of these mutations.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Effects of mutagen-sensitive mus mutations on spontaneous mitotic recombination in Aspergillus
Article Abstract:
The effects of eight mutations of the mus locus of Aspergillus nidulans on mitotic recombination were studied. Two of the mutations increased, while another two decreased inter- and intragenic recombination. The musO mutation increased only intragenic recombination. The product of the musL mutation appeared necessary for recombination and its absence resulted in chromosome loss. The behavior of some mutants suggested differential effects on the related events of mitotic gene conversion and crossing over.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
nuvA, an Aspergillus nidulans gene involved in DNA repair and recombination, is a homologue of Saccharomyces cerevisiae RAD18 and Neurospora crassa uvs-2
Article Abstract:
The nuv A gene plays an important role in DNA repair and recombination in Aspergillus nidulans. The cloning of the nuv A gene is undertaken by complementing it with the nuvA11 phenotype. The isolation of the nuv cDNA sequence is described and the location of the nuv A gene on chromosome IV is determined. Results indicate that the nuv A gene is a homologue of the known DNA repair proteins uvs-2 in Neurospora crassa and RAD18 in Saccharomyces cerevisiae.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Seventeen complementation groups of mutations decreasing meitotic recombination in Schizosaccharomyces pombe. Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe
- Abstracts: In situ PCR for visualization of microscale distribution of specific genes and gene products in prokaryotic communities
- Abstracts: S elements: a family of Tc1-like transposons in the genome of Drosophila melanogaster. Genetic instability in Drosophila melanogaster mediated by hobo transposableelements
- Abstracts: Does hybrid lethality depend on sex or genotype? Dominance and Haldane's rule. Meiotic drive and unisexual hybrid sterility: a comment