Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
Article Abstract:
The functional relationships between the two tumor suppressors, namely, tuberous sclerosis complex (TSC) and Peutz-Jeghers syndrome (PJS), which are dominantly inherited benign tumor syndromes sharing striking histopathological similarities are examined. The regulation of the TSC pathway by LKB1, which acts a tumor suppressor by activating TSC2, the gene mutated in TSC reveals that PJS and other benign tumor syndromes can be caused by dsyregulation of the TSC2/mammalian target of rapamycin (mTOR) pathway.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Nuclear myosin I acts in concert with polymeric action to drive RNA polymerase I transcription
Article Abstract:
Actin and nuclear myosin I (NM1) act in concert to promote RNA polymerase I (Pol1) transcription. The cooperative action of actin and myosin in the nucleus and actin polymerization and the motor function of NM1 are required for association with the Pol I transcription machinery and transcription activation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
- Abstracts: Detection of staphylococcal enterotoxin B via biomolecular interaction analysis mass spectrometry
- Abstracts: The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Functional siRNAs and miRNAs exhibit strands bias
- Abstracts: Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. Mouse-centric comparative transcriptomics of protein coding and non-coding RNAs
- Abstracts: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response