Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease
Article Abstract:
Study is presented to show that Brg1, the ATPase subunit of the Swi/Snf complex, is essential for trans-repression and that Brg1 is required in vivo to stabilize interactions between glucocorticoid receptor (GR) and NGFI-B as well as between GR and HDAC2. It is found that ~50% of pituitary adenomas from Cushing disease patients have misexpression of either Brg1 or HDAC2 in tumor tissue but not in adjacent normal pituitary tissue.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
Article Abstract:
A demonstration that targeted ablation of the integrim-linked kinase (ILK) expression results in spontaneous cardiomyopathy and heart failure by 6 wk of age is presented. The results suggest that ILK plays a vital role in protecting the mammalian heart against cardiomyopathy and failure.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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The lateral line microcosmos
Article Abstract:
The article discusses about the progress made in the field of lateral-line sensory system over the past few years.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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