SCF (super beta-TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase
Article Abstract:
A requirement for SCF (super beta-TRCP) in Cdc25A (tyrosine phosphatases) turnover during an unperturbed cell cycle and in response to DNA damage is demonstrated. The data indicates that Cdc25A turnover is more complex than previously appreciated and suggest roles for an additional kinase(s) in Chk1-dependent Cdc25A turnover.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
Article Abstract:
A direct regulatory linkage between the protein serinethreonine phosphatase 5 (PP5) and a serine-threonine kinase, ATM is reported. The role of PP5 in the activation and checkpoint signaling functions of ATM in cells that have suffered DNA double-strand breaks is highlighted.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Chk1 activation requires Rad9 S/TQ-site phosphorylatio to promote association with C-terminal BRCT domains of Rad4(super TOPBP1)
Article Abstract:
The phosphorylation of the Schizosaccharomyces pombe PCNA-like checkpoint protein Rad9 is investigated to gain insight into the function and organization of proteins assembled on the DNA. Rad9 C-terminal phosphorylation allows Rad9 to interact with the TOPBP1 homolog Rad4.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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