Sculpting the proteome with AAA+ proteases and disassembly machines
Article Abstract:
The machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA+ ATPase family-function in all kingdoms of life to sculpt the cellular proteome ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Enzymes of the AAA+ ATPase family play critical role in this sculpting of the proteome in all organisms.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans
Article Abstract:
The role of ubiquitin-conjugating enzyme (UBC)-18 and ARI-1, an Ariadnean ubiquitin-ligase in controlling the development of the pharynx in Caenorhabditis elegans is discussed.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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