Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide
Article Abstract:
Secretory leukocyte protease inhibitor (SLPI), a known epithelial cell-derived inhibitor of leukocyte serine proteases, is transcribed by lipopolysaccharide (LPS)-hyporesponsive cells, primary macrophages and polymorphonuclear leukocytes. It can be considered a phagocyte-derived LPS-induced LPS inhibitor due to its sources, functions and modes of regulation. It is one of the few genes whose expression in macrophages is induced by LPS and suppressed by interferon-gamma (IFN-gamma). IFN-gamma suppressed expression of SLPI and restored LPS responsiveness to SLPI-producing cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Natural resistance and nitric oxide
Article Abstract:
The immunity-conferring ability of natural resistance-associated macrophage protein 1 (NRAMP 1) of mouse chromosome 1 is probably due to its mobilization of the antimicrobial nitric oxide (NO). NRAMP 1 pumps nitrite from the extracellular fluid into cells where it is converted into NO. The transfection of inducible isoform NO synthase or NO into cells makes them resistant to many infectious organisms. A family of genes related to NRAMP1 has been conserved in rodents and mammals. But no resistance due to NRAMP1 related genes has been observed in mammals.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
Article Abstract:
The function of inducible nitric oxide synthase (iNOS) in preventing infections was determined by examining the response of mice lacking iNOS to tissue damage and shock. Wild-type mice exhibited high risk to shock and death upon exposure to bacterial endotoxic lipopolysaccharide (LPS), but iNOS mice were protected to collapse and shock. This suggests that iNOS deficiency increases risk to damage, shock and infections.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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