Segment-polarity mutations cause stripes of defects along a leg segment in Drosophila
Article Abstract:
A study was conducted on the effects of mutations in 6 segment-polarity (SP) genes and their 15 pairwise compounds on bristle patterns in the second-leg barsitarsi of Drosophila. Results revealed that abnormal patterning within defined areas of the imaginal discs were produced by SP mutations. In particular, specific rows, or portions of them, have been deleted and bristle number increased within or between specific rows. These abnormalities were linked to width changes in different parts of the circumference and suggested that altered bristle patterns might have been mediated by regional growth perturbations.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb
Article Abstract:
Researchers discovered a homeobox-containing gene, Prx-1, isolated from the chick limb bud cDNA library. The homeodomain sequence is associated with Drosophila paired and gooseberry and mouse Pax-3, Pax-6 and Pax-7. The Prx-1 homeodomain protein is related to the differentiation of bone, muscle and other tissues of mesodermal origin during limb growth.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Mutations modulating Raf signaling in Drosophila eye development
- Abstracts: Replication arrest. Archaea and the origin(s) of DNA replication proteins. The transactivator proteins VP16 and GAL4 bind replication factor A
- Abstracts: Ultraviolet-induced mutation and the chemical nature of the gene. Thirty years ago in genetics: prophage insertion into bacterial chromosomes
- Abstracts: Gustave Malecot, 1911-1998: population genetics founding father. A genetic model for control of hypertriglyceridemia and apolipoprotein B levels in the John Hopkins colony of St. Thomas Hospital rabbits
- Abstracts: Binding of germ cells to mutant Sl(super d) Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand. part 2