Yeast heterochromatin is a dynamic structure that requires silencers continuously

Article Abstract:

Site-specific recombination has been used to uncouple already-assembled silent chromatin fragments from silencers, and it was found that yeast heterochromatin has a dynamic structure. The structure requires silencers continuously.

Saccharomyces

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Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein

Article Abstract:

Evidence that CBP/p300-interacting transactivators with glutamic acid (E)/aspartic acid (D)-rich C-terminal domain 1 (CITED1) acts as a selective coactivator for estrogen-dependent transcription has been found. CITED1 seems to have gene-specific regulatory roles in estrogen sensitivity.

Japan, Statistical Data Included, Estrogen, Estrogen receptors

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A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb

Article Abstract:

C-terminal domain (CTD) analogs and the transcriptional repressor PIE-1 are discussed as a model of repression and with regard to their inhibition of transcriptional elongation by positive transcription elongation factor b (P-TEFb). A new mechanism for repressors inhibiting eukaryotic transcription has been found . Alanin-substituted heptapeptide repeats that cannot be phosphorylated have been found to bind cyclin T1 (CycT1). The CTD analogs block effects of P-TEFb if n ear transcription units. The Caenorh abditis elegans transcriptional repressor PIE-1 behaves analogously .

Science & research, Slovenia, Genetic aspects, Eukaryotes, Caenorhabditis elegans

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