Short dysfunctional telomeres impair tumorigenesis in the INK4aDelta2/3 cancer-prone mouse
Article Abstract:
Successive generations of mice doubly null for the tolemerase RNA (mTR) and the INK4a tumor suppressor genes were examined to determine the effect of telomere dysfunction on tumorigenesis. Results indicate that tumor growth in vivo and oncogenic potential in vitro in late generations of telomerase deficiency were slowed down. However, the reintroduction of mTR into the cells was not abe to fully stop tumor formation. It only restored the cell's oncogenic potential.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
Article Abstract:
A study was conducted to investigate the relationship of the telomere dysfunction and p53 in cells and organs of telomerase-deficient mice. Results indicate that p53 activation that induces growth arrest and /or apoptosis is influenced by severe telomere shortening and genomic instability. It was also found that the removal of p53 weakens the adverse cellular and organismal effects of telomere dysfunction during the first stages of genetic crisis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
Article Abstract:
Research demonstrates that telomere dysfunction is mediated by shortest telomeres leading to cell cycle arrest and apoptosis. Karyotype analysis of the cross between short telomere and long telomere mice reveal that loss of telomere function occurs on chromosomes with short telomeres.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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