Short-range and long-range guidance by slit and its Robo receptors: A combinatorial code of robo receptors controls lateral position

Article Abstract:

Research reveals that the lateral position in the central nervous system is controlled through a response to the Slit gradient. Data further show that that the process of central nervous axon guidance to the longitudinal pathway is mediated by Slit and its family of Robo receptors.

United States, Research, Central nervous system, Neural receptors, Combinatorial chemistry

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Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila

Article Abstract:

Genetic analyses of glioactin, a transmembrane protein in Drosophila expressed on embryonic peripheral glia, indicates its role in the formation of the blood-nerve barrier. However, in glioactin mutant embryos, it was shown that the peripheral glia do not form a complete blood-nerve barrier. Instead of shielding motor and sensory axons from the high potassium concentration of the hemolymph, the peripheral glia expose the axons. These results to termination of the action potentials and paralysis of the embryos.

Nervous system, Nerves, Peripheral, Peripheral nerves

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Chimeric axon guidance receptors: the cytoplasmic domains of Slit and Netrin receptors specify attraction versus repulsion

Article Abstract:

A transgenic Drosophila was studied to assess the modular functions of the domains of two chimeric axon guidance receptors, namely, Frazzled (FRA), a Deleted in Colorectal Cancer-like Netrin receptor, and Roundabout (Robo), a Slit receptor. Results indicate that Fra's ectodomain and Robo's cytoplasmic domain act as a repulsive Netrin receptor. Hence, neurons carrying Fra-Robo steer clear from Netrin-expressing midline and muscles. On the other hand, Robo's ectodomain and Fra's cytoplasmic domain function as an attractive Slit receptor, and thus, interact with Slit-expressing midline.

Cell receptors, Fruit-flies, Cytoplasm

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