Signal transduction and invasion of epithelial cells by S. typhimurium
Article Abstract:
Invasion of cultured epithelial cells by Salmonella typhimurium is associated with epidermal growth factor receptor (EGFR) activation. An investigation was conducted to elucidate the signal transduction pathway activated by EGFR leading to epithelial cell invasion. Specific components of the pathway were identified to be intracellular Ca2+, phospholipase A2 and leukotriene D4. Based on these results, a model for the signal transduction events in Salmonella invasion of cultured epithelial cells is presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Signal transduction schemes of bacteria
Article Abstract:
Bacteria have evolved sophisticated adaptive measures to deal with the pressure of constant life and death decisions. The movements of cells towards favorable conditions and away from toxic ones illustrates these survival measures. Bacteria also exhibit regulatory responses such as the appearance of nutrients that sets off the production of transport and metabolic mechanisms needed to reach these nutrients. Bacteria react to lean periods by forming cell aggregates that ripen into bodies with resting spores.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Signal transduction in the mammalian cell during bacterial attachment and entry
Article Abstract:
The consequences borne by the host cell of the attachment of a microbe to its cellular target were found to be a biochemical battle in miniature. The defense mechanisms are designed to deny access to microorganisms and the microbe's genetic apparatus has been selected to overcome these defenses. Disease is not a necessary aftermath of this interplay.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
User Contributions:
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